Lot-to-lot variation in anti-hepatitis C signal-to-cutoff ratio.
نویسنده
چکیده
Lot-to-Lot Variation in Anti-Hepatitis C Signal-to-Cutoff Ratio, D. Robert Dufour (Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, and Department of Pathology, The George Washington University Medical Center, Washington, DC; address for correspondence: Pathology and Laboratory Medicine Service-113, Veterans Affairs Medical Center, 50 Irving St. NW, Washington DC 20422; fax 202-745-8284, e-mail [email protected])
منابع مشابه
Improved Reflexive Testing Algorithm for Hepatitis C Infection Utilizing Signal-to-Cutoff Ratios of a Hepatitis C Virus Antibody Assay
BACKGROUND: Chemiluminescence immunoassay (CIA) is used to detect hepatitis C virus (HCV) antibody status on the basis of signal-to-cutoff (S/Co) ratios. Positive results of antibody to HCV (anti-HCV) are followed by either recombinant immunoblot assay (RIBA) to confirm anti-HCV positivity or reverse transcription (RT)-PCR to detect viremia. We hypothesized that by analyzing S/Co ratios, we cou...
متن کاملSignificance of Anti-HCV Signal-to-Cutoff Ratio in Predicting Hepatitis C Viremia
BACKGROUND/AIMS Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) for predicting HCV RNA results. METHODS Patients on whom a qualitative HCV RNA test was perform...
متن کاملImproved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay.
BACKGROUND Chemiluminescence immunoassay (CIA) is used to detect hepatitis C virus (HCV) antibody status on the basis of signal-to-cutoff (S/Co) ratios. Positive results of antibody to HCV (anti-HCV) are followed by either recombinant immunoblot assay (RIBA) to confirm anti-HCV positivity or reverse transcription (RT)-PCR to detect viremia. We hypothesized that by analyzing S/Co ratios, we coul...
متن کاملRole of signal-to-cutoff ratios in hepatitis C virus antibody detection.
We reviewed results from 12,800 samples tested for hepatitis C virus (HCV) antibody detection in our laboratory by screening (Ortho chemiluminescence immunoassay [CIA]) and supplemental tests (Chiron recombinant immunoblot assay [RIBA]). We found that a signal-to-cutoff (S/Co) ratio of 10.3 was, in our setting, the most efficient cutoff point to improve the diagnostic algorithm of HCV infection.
متن کاملCombating Hepatitis C (HCV): A Review of Present & Future Perspectives
Abstract: Over the past few decades, the race against the treatment strategies of infectious HCV has gained a lot of momentum. These treatments include several therapies like Ribavirin, INF-α, DAA based pro-drugs, vaccines, and even naturally occurring compounds like herbal extracts as well as scorpion venom. All of these drugs have their specialized techniques and methodologies of administrati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical chemistry
دوره 50 5 شماره
صفحات -
تاریخ انتشار 2004